Big Data

Translating Big Data into Decision Support systems?

How to go from Big Data to Decision Support systems:

A point in a recent JAMIA editorial suggests interesting questions on the design of systems for research and for clinical practice, and the required technical specifications:

“… in most academic health systems there is still a clear separation between basic and translational research involving genome data and clinical research. Computational environments […]

Definitions: Efficacy, Effectiveness, Efficiency

Borrowing from
John Marley, Professor, Department of General Practice, University of Adelaide, Adelaide
Aust Prescr 2000;23:114-5
http://www.australianprescriber.com/magazine/23/6/114/5

Efficacy –  can a treatment work?
As in a clinical trial, i.e. in ideal circumstance of a controlled trial population.

Effectiveness – ‘the extent to which a drug achieves its intended effect in the usual clinical setting’

Effectiveness “can be evaluated through observational studies of real practice”; local and […]

On DNA big data for drug discovery

A Featured Story on The MIT Technology Review, by Antonio Regalado (November 19, 2014) about how drug companies are using “giant database of human DNA information” for drug discovery.
Entitled The Search for Exceptional Genomes, this story provides an example of how Big Data can be used by drug manufacturers to explore new drugs.

http://www.technologyreview.com/featuredstory/532421/the-search-for-exceptional-genomes/?utm_campaign=newsletters&utm_source=newsletter-daily-all&utm_medium=email&utm_content=20141119

…“This is going to be […]

Precision medicine and a New Taxonomy of Disease

A Report published in 2011, explains a US initiative to develop a potential framework for “a New Taxonomy of human disease based on molecular biology”:

A Knowledge Network of Disease could embrace and inform rapidly expanding efforts by the biomedical research community to define at the molecular level the disease predispositions and pathogenic processes occurring in individuals. This network […]

Big Data in Vs dimensions…

“…The four big Vs are: Velocity, because it’s ‘live’ and coming in all the time, e.g. Twitter, Flickr; Variety, because there’s so many different kinds, from images (YouTube), to text (blogs), to numbers (transactions, automated logs); Veracity, because it’s uncertain or imprecise and we don’t always know what’s there; and Volume, because there’s so much of it, it’s big. […]

July 23rd, 2014|Big Data|0 Comments|

Big pharma and smart devices

An article on the Financial Times, commenting on Google links with Novartis, to develop a “smart” contact lens designed to help diabetics track their blood sugar levels.

http://www.ft.com/cms/s/0/9738eec8-0c0e-11e4-9080-00144feabdc0.html#axzz3L2n2ppuU

It also mentions the “electroceuticals” – “implants that use electronic impulses to affect and modify the functions of the body”

July 16th, 2014|Big Data|0 Comments|

NHS England, Genomics England and the 100K Genome project

News from eHealth Insider

“NHS England expects to have contracts in place with providers by January 2015 for its ambitious project to sequence 100,000 genomes and link the results with a national database of electronic patient records”.

The aim is “to have the 100,000 genome sequences done by the end of 2017 and it is launching a process for selecting ‘NHS […]

Translational Bioinformatics – a definition

“Translational Bioinformatics is the development of storage, analytic, and interpretive methods to optimize the transformation of increasingly voluminous biomedical data, and genomic data, into proactive, predictive, preventive, and participatory health. Translational bioinformatics includes research on the development of novel techniques for the integration of biological and clinical data and the evolution of clinical informatics methodology to encompass biological observations. […]

Social networks ‘big data’ + drug manufacturing

PatientsLikeMe, the largest online network for patients, has established its first broad partnership with a drug company. Genentech
http://www.technologyreview.com/

New book: big data / raw data

Gitelman, Lisa. Raw Data Is an Oxymoron. MIT Press, 2013.

http://mitpress.mit.edu/books/raw-data-oxymoron

March 8th, 2014|Big Data|0 Comments|