Medicalisation, medicines for millions

Denis Pereira Gray,  Eleanor White,  and Ginny Russell,  Medicalisation in the UK: changing dynamics, but still ongoing J R Soc Med 0141076815600908, first published on October 2, 2015 doi:10.1177/0141076815600908

[…] general medical practice has reversed from being mainly reactive work with doctors responding to patients’ symptoms, to a pro-active mass assessment of risk with extensive issuing of treatments, increasingly for […]

January 29th, 2016|Medicines|0 Comments|

Being a 10 mg donepezil drug, or not

A patient who received a labeled dose of 10 mg of donepezil per day for 3 months that was purchased from Canada could have been receiving only 6.3 mg per day..
Wang, Chong-Zhi; Du, Guang-Jian; Zhen, Zhong; Calway, Tyler; Yuan, Chun-Su(2011) Significant Dose Differences in Donepezil Purchased From the United States and Canada
Annals of Internal Medicine
Issue: Volume 155(4), 16 August 2011, pp […]

Stratified Medicine in 2015 – Leeds Christmas Lecture

Professor Sir Munir Pirmohamed, NHS Chair of Pharmacogenetics, Professor of Medicine, Liverpool School of Medicine, and Director of the Wolfson Centre for Personalised Medicine, gave a a Christmas lecture at the Faculty of Medicine and Health, University of Leeds, on stratified and precision medicine.

Stratified Medicine in 2015 – challenges and opportunities
Wednesday 9th December 2015, the Leeds Medical School Lecture Theatre, […]

Patient portals for patient adherence – evidence of effects

A controlled study about the effect of patients using an online refill tool (repeat prescription request system) on their adherence to statins :

Courtney R. Lyles, Urmimala Sarkar, Dean Schillinger, James D. Ralston, Jill Y. Allen, Robert Nguyen, Andrew J. Karter, Refilling medications through an online patient portal: consistent improvements in adherence across racial/ethnic groups, Journal of the American Medical […]

November 30th, 2015|Medicines, Research|0 Comments|

The Contrasting Medicines Regulatory Environments of China and the Western World

For purposes of anticounterfeiting and pharmacovigilance, “in our world of economic unions and free trade agreements, a country’s drug regulations are only as good as its weakest import partner”.


Peter J. Harris and Ian C. Shaw (2015) The Contrasting Medicines Regulatory Environments of China and the Western World, Pharmaceutical Medicine, First online: 16 October 2015 :


Note: the reference list […]

Asking (right) questions – or medicines can kill you

This week a column from the Guardian, invites doctors and professional journals to ask the right questions – questions about the evidence, and questions about what matters to patients:

Aseem Malhotra, How too much medicine can kill you, The Guardian, Sunday 1 November 2015

Here a few snippets, with links to resources:
“According to Peter Gøtzsche, professor of research design and […]

Precision medicine on BBC Radio 4 Today Programme

Precision medicine  was on the BBC Today programme, yesterday 29 October 2015.

Dr Anna Schuh, associate professor of molecular diagnostics at Oxford University and director of the Genomic Medicine Centre, and Professor Richard Barker, head of the Centre for the Advancement of Sustainable Medical innovation and chair of the government’s Precision Medicine Catapult, were interviewed about recent results of a […]

11 biases, blinding statistics and leaps of imagination, or how does one ends up taking a medicine (or not)

Mrs B goes to the GP, having just visited the cardiology clinic. The discharge letter from the specialist registrar states: “Could you please start [Mrs B] on spironolactone 25mg daily and monitor her electrolytes in two weeks” …

Will Mrs B be prescribed spironolactone? No spoiler here!

Read this insightful delightful case study of how GPs make decisions about prescribing medicines. […]

Market prices, Market games

September 3: a paper in NEJM about drug companies claiming the First Amendment (free speech) to advertise drugs to patients beyond FDA regulation.

September 21: on The Guardian the news of a drug company raising the price 50 times (from $13.50 a pill to $750), and of Clinton’s campaign against it.

September 29: BBC Radio4 FileOn4 ‘Missing Medicines’ about the NHS […]

Non-adherence to prescriptions is categorical construct. Non-persistence adds a time dimension to it

In a move to a more balanced doctor-patient relationship, and shared decision making, we have long moved from concepts of patient’s ‘compliance’ to ideas of ‘adherence’ and ‘concordance’ with/to prescription  (For definition of the three labels, and their implications, see for example the 2005 Report for the National Co-ordinatingCentre for NHS Service Delivery and Organisation R & D).

It is […]

September 14th, 2015|Clinical use, Medicines|0 Comments|